Calcium is a key factor in α-synuclein induced neurotoxicity
نویسندگان
چکیده
Plamena R. Angelova, Marthe H.R. Ludtmann, Mathew H. Horrocks, Alexander Negoda, Nunilo Cremades, David Klenerman, Christopher M. Dobson, Nicholas W. Wood, Evgeny V. Pavlov, Sonia Gandhi, Andrey Y. Abramov UCL Institute of Neurology, Queen Square, London WC1N 3BG, UK; 2 Department of Chemistry, University of Cambridge, Cambridge, UK; 3 Department of Physiology and Biophysics, Dalhousie University, Halifax, Canada;; College of Dentistry, New York University, New York, USA
منابع مشابه
Calcium: Alpha-Synuclein Interactions in Alpha-Synucleinopathies
Aggregation of the pre-synaptic protein, α-synuclein (α-syn), is the key etiological factor in Parkinson's disease (PD) and other alpha-synucleinopathies, such as multiple system atrophy (MSA) and Dementia with Lewy bodies (DLB). Various triggers for pathological α-syn aggregation have been elucidated, including post-translational modifications, oxidative stress, and binding of metal ions, such...
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